Fosamax, the osteoporosis medication linked to rare bone fractures and birth defects, may also increase the risk of throat cancer.
How can a drug that strengthens bones cause esophageal cancer? Bisphosphonates like Fosamax, Boniva, and Actonel irritate the lining of the esophagus, causing esophagitis or esophageal ulcers. These conditions are known risk factors for esophageal cancer.
In 2011, the U.S. Food and Drug Administration (FDA) issued a Drug Safety Communication,announcing that it was evaluating the link between bisphosphonates like Fosamax and esophageal cancer. At that time, there was conflicting evidence as to whether or not bisphosphonates could cause cancer of the esophagus. A British study found no link between the use of bisphosphonates and cancer of the esophagus, but other studies found an increased risk of esophageal cancer in patients who took bisphosphonates for more than three years and in patients who had ten or more prescriptions for bisphosphonates.
In 2012, doctors at Northwestern University reviewed the FDA’s own Adverse Events Reporting System (FDA AERS) database records from 1996 to 2010. They searched for instances of esophageal cancer associated with bisphosphonate use. These are the findings:
- 128 cases of bisphosphonate-associated esophageal cancer
- 96 cases associated with Fosamax
- 14 cases associated with Actonel
- 10 cases associated with Boniva
- 8 cases associated with injectable bisphosphonates
In 2009, there were only 23 reports of esophageal cancer associated with Fosamax, and none associated with other oral bisphosphonates. The researchers believe these numbers show that the risk of cancer from osteoporosis drugs is much higher than indicated by prior studies. The findings were presented at 48th the Annual Meeting of the American Society of Clinical Oncology.
The FDA is still investigating the risks associated with Fosamax, but you don’t have to wait for their decision. If you suffered esophageal cancer after using Fosamax, science is on your side. Consult a Salt Lake City pharmaceutical injury attorney to learn about Fosamax cancer claims. You may be eligible for compensation for your medical bills, lost wages, and loss of quality of life. To learn more, schedule a free consultation with the James Esparza Law Firm at 800-745-4050.